- Abciximab drug
- Abciximab action
- Abciximab mg
- Abciximab standard dose
- Abciximab uses
- Abciximab abciximab brand name
- Abciximab names
- Abciximab brand name
- Abciximab injection
Advice to Patients
Risk of serious bleeding or hemorrhage.1 4 5 9
Importance of close laboratory monitoring.1
Importance of informing clinicians of existing or contemplated therapy, including prescription and OTC drugs and dietary or herbal supplements, as well as any concomitant illnesses (e.g., cardiovascular disease).1
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1
Importance of advising patients of other important precautionary information.1 (See Cautions.)
Fab antibody fragment of the chimeric human-murine monoclonal antibody 7E3; this agent binds to platelet IIb/IIIa receptors, resulting in steric hindrance, thus inhibiting platelet aggregation
Vd: 0.07 L/kg (Schror 2003)
Unbound abciximab metabolized via proteolytic cleavage (Schror 2003)
Onset of Action
Rapid; platelet aggregation reduced to <20% of baseline at 10 minutes
Time to Peak
Platelet inhibition: ~30 minutes (Mascelli 1998)
Refer to adult dosing.
Bolus dose: Withdraw required amount of abciximab into a syringe using a 0.2 or 5 micron low protein-binding syringe filter (or equivalent); the bolus should be administered 10 to 60 minutes before the procedure.
Continuous infusion: Withdraw required amount of abciximab into a syringe using a 0.2 or 5 micron low protein-binding syringe filter (or equivalent) and inject into an appropriate container of NS or D5W. If a syringe filter was not used to prepare the infusion, administer using an in-line 0.2 or 0.22 micron low protein-binding filter.
Note: A standard concentration of 7.2 mg in 250 mL of NS or D5W may also be prepared for all patients and administered at the standard dose (0.125 mcg/kg/minute; maximum: 10 mcg/minute) with a variable rate in mL/hour. Infuse for 12 to 24 hours via pump after bolus dose; length of therapy dependent on indication. Some institutions use a standard concentration of 9 mg in 250 mL of D5W or NS.
Abciximab has the potential to increase the risk of bleeding events, rarely including those with a fatal outcome, particularly in the presence of anticoagulation, e.g., from heparin, other anticoagulants, or thrombolytics (see ADVERSE REACTIONS: Bleeding).
The risk of major bleeds due to Abciximab therapy is increased in patients receiving thrombolytics and should be weighed against the anticipated benefits.
Should serious bleeding occur that is not controllable with pressure, the infusion of Abciximab and any concomitant heparin should be stopped.
Allergic Reactions (including anaphylaxis)
Allergic reactions, some of which were anaphylaxis (sometimes fatal), have been reported rarely in patients treated with ReoPro. Patients with allergic reactions should receive appropriate treatment. Treatment of anaphylaxis should include immediate discontinuation of ReoPro administration and initiation of resuscitative measures.
Uses of Abciximab
Abciximab is a prescription medication used to prevent blood clots from forming during a percutaneous coronary intervention (PCI). This is a procedure done to open narrowed or blocked blood vessels that supply blood to the heart.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Abciximab Brand Names
Abciximab may be found in some form under the following brand names:
Dosing & Uses
Dosage Forms & Strengths
Adjunct to PCI
Prevention of cardiac ischemic complications in patients undergoing PCI
0.25 mg/kg IV bolus over at least 1 min, 10-60 min before start of PCI, THEN
0.125 mcg/kg/min IV continuous infusion for 12 hr; not to exceed infusion rate of 10 mcg/min
Indicated for prevention of cardiac complications in patients with unstable angina with PCI planned within 24 hr
0.25 mg/kg IV bolus over at least 1 minute, THEN
0.125 mcg/kg/min IV continiuous infusion for 18-24 hr concluding 1 hour post-PCI; not to exceed 10 mcg/min
Stop continuous infusion of abciximab in patients with failed PCIs
Other Indications & Uses
Adjunctive therapy during thrombolysis (off-label)
Safety and efficacy not established
Solution: D5W, NS
Y-site: adenosine, atropine, bivalirudin, diphenhydramine, fentanyl, metoprolol, midazolam
Do not add any other drugs in same IV line
Bolus injection: withdraw through 0.22 micron filter
Infusion: withdraw 4.5 mL (9 mg) through filter into syringe; inject into 250 mL of NS or D5W; final concentration 35 mcg/mL
Do not shake vial
Bolus over at least 1 min
See adult dosing for infusion rate