Acetaminophen-hydrocodone Oral Tablet

Name: Acetaminophen-hydrocodone Oral Tablet

What is acetaminophen-hydrocodone?

Acetaminophen-hydrocodone is a prescription medication and a controlled substance. It comes as an oral tablet and an oral solution.

Acetaminophen-hydrocodone is available as the brand-name drugs Norco and Vicodin. It’s also available in its generic form. Generic drugs usually cost less than brand-name drugs. In some cases, they may not be available in every strength or form as the brand-name version.

This medication is a combination of two or more drugs in a single form. It’s important to know about all the drugs in the combination because each drug may affect you in a different way.

Why it's used

This medication is used to treat moderate to severe pain.

How it works

This medication is a combination of hydrocodone and acetaminophen. Hydrocodone is an opioid (narcotic), and acetaminophen is an analgesic (pain reliever). Both drugs are used to reduce pain.

These drugs work in your brain to block pain signals. They decrease your ability to feel pain.

Acetaminophen-hydrocodone side effects

Acetaminophen-hydrocodone oral tablet may make you feel sleepy, dizzy, or lightheaded. Avoid driving a car or using machinery until you know how your body reacts to this medication.

This drug can also cause other side effects.

More common side effects

The more common side effects that occur with acetaminophen-hydrocodone include:

  • sleepiness or drowsiness
  • feeling dizzy or lightheaded
  • nausea
  • vomiting
  • constipation

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • skin rash
  • swelling of your face, throat, and mouth
  • liver problems, including liver failure. Symptoms may include:
    • yellowing of your skin and the whites of your eyes
    • pain in the upper right part of your stomach area
    • swelling of your stomach area
    • itchiness
    • confusion
    • feeling tired
    • lack of appetite
  • trouble breathing
  • drug dependence

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Acetaminophen-hydrocodone may interact with other medications

Acetaminophen-hydrocodone oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with promethazine are listed below.

Drugs that cause drowsiness

Taking these drugs with acetaminophen-hydrocodone increases your risk of drowsiness, dizziness, tiredness, and reduced physical and mental function. If you need to use both drugs together, the dosage of one or both drugs should be reduced.

These drugs include:

  • other opioids (narcotics)
  • antihistamines, which are used for allergies
  • antipsychotics, which are used for bipolar disorder, schizophrenia, or depression
  • benzodiazepines, which are used for anxiety

Antidepressants

Taking monoamine oxidase inhibitors or tricyclic antidepressants with acetaminophen-hydrocodone may increase your levels of either drug in your body. This could result in more side effects.

Drugs that increase serotonin

Taking this medication with drugs that increase the amount of a chemical called serotonin in your body can cause a serious problem. This problem is called serotonin syndrome and it can be fatal. Tell your doctor if you are taking any of these medications:

  • some antidepressants (selective serotonin reuptake inhibitors [SSRIs], selective serotonin and norepinephrine reuptake inhibitors [SNRIs], tricyclic antidepressants [TCAs], monoamine oxidase inhibitors [MAOIs], mirtazapine, trazodone)
  • certain drugs for migraine (triptans)
  • certain drugs for nausea, such as ondansetron
  • tramadol, which is used for pain
  • linezolid, which is an antibiotic

Drugs that decrease activity of certain enzymes in the liver

Taking this medication with drugs that can decrease activity of certain liver enzymes can increase the amount of hydrocodone or acetaminophen in your body and cause more side effects. You may have increased breathing problems or drowsiness. Examples of these drugs include:

  • erythromycin
  • ketoconazole
  • protease inhibitors used to treat HIV, such as ritonavir

Drugs that increase activity of certain enzymes in the liver

Taking this medication with drugs that can increase activity of certain liver enzymes can lower the amount of hydrocodone or acetaminophen in your body. You may need a higher dose of this medication to control your pain. Examples of these drugs include:

  • rifampin
  • carbamazepine
  • phenytoin

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

How to take acetaminophen-hydrocodone

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

Forms and strengths

Generic: Acetaminophen-hydrocodone

  • Form: oral tablet
  • Strengths:
    • hydrocodone 5 mg/acetaminophen 300 mg
    • hydrocodone 7.5 mg/acetaminophen 300 mg
    • hydrocodone 10 mg/acetaminophen 300 mg
    • hydrocodone 2.5 mg/acetaminophen 325 mg
    • hydrocodone 5 mg/acetaminophen 325 mg
    • hydrocodone 7.5 mg/acetaminophen 325 mg
    • hydrocodone 10 mg/acetaminophen 325 mg

Brand: Norco

  • Form: oral tablet
  • Strengths:
    • 5 mg hydrocodone/325 mg acetaminophen
    • 7.5 mg hydrocodone/325 mg acetaminophen
    • 10 mg hydrocodone/325 mg acetaminophen

Brand: Vicodin

  • Form: oral tablet
  • Strength: 5 mg hydrocodone/300 mg acetaminophen

Brand: Vicodin ES

  • Form: oral tablet
  • Strength: 7.5 mg hydrocodone/300 mg acetaminophen

Brand: Vicodin HP

  • Form: oral tablet
  • Strength: 10 mg hydrocodone/300 mg acetaminophen

Dosage for moderate to severe pain

Adult dosage (ages 18 years and older and weighing at least 101 pounds [46 kg])

  • 5 mg or 2.5 mg hydrocodone / 300 mg or 325 mg acetaminophen: The typical dosage is 1–2 tablets taken every 4–6 hours as needed. The maximum dosage is 8 tablets per day.
  • 7.5 mg or 10 mg hydrocodone / 300 mg or 325 mg acetaminophen: The typical dosage is 1–2 tablets taken 4–6 hours as needed. The maximum dosage is 6 tablets per day.

Child dosage (ages 0–17 years)

  • Dosage for people younger than 18 years hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you. 

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