Acetohydroxamic acid

Name: Acetohydroxamic acid

What Is Acetohydroxamic Acid?

Acetohydroxamic acid helps prevent a build-up of ammonia in urine that can be caused by a bladder infection. Increased ammonia in urine can cause the growth of kidney stones.

Acetohydroxamic acid is used to keep urine ammonia levels low in people who have a certain type of chronic bladder infection.

Acetohydroxamic acid is not an antibiotic and will not treat the infection itself. This medicine is only part of a treatment program that may also include antibiotics to treat the infection, and surgery to remove kidney stones. Follow your doctor's instructions very closely.

Acetohydroxamic acid may also be used for purposes not listed in this medication guide.

You should not use acetohydroxamic acid if you have kidney disease, or if you have bladder symptoms that have not been checked by a doctor.

This medicine can harm an unborn baby or cause birth defects. Do not use acetohydroxamic acid if you are pregnant or if you are not using birth control.

You should not use acetohydroxamic acid if you are allergic to it, or if you have:

  • kidney disease;
  • bladder symptoms that have not been checked by a doctor with lab tests; or
  • if you are pregnant or are not using birth control.

To make sure acetohydroxamic acid is safe for you, tell your doctor if you have:

  • liver disease;
  • hemolytic anemia (a lack of red blood cells); or
  • a weak immune system.

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not use acetohydroxamic acid if you are pregnant. Use effective birth control to prevent pregnancy while taking acetohydroxamic acid. Tell your doctor right away if you become pregnant or if you stop using birth control for any reason during treatment with this medicine.

It is not known whether acetohydroxamic acid passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

What should I discuss with my health care provider before taking acetohydroxamic acid?

You should not use acetohydroxamic acid if you are allergic to it, or if you have:

  • kidney disease;

  • bladder symptoms that have not been checked by a doctor with lab tests; or

  • if you are pregnant or are not using birth control.

To make sure acetohydroxamic acid is safe for you, tell your doctor if you have:

  • liver disease;

  • hemolytic anemia (a lack of red blood cells); or

  • a weak immune system.

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not use acetohydroxamic acid if you are pregnant. Use effective birth control to prevent pregnancy while taking acetohydroxamic acid. Tell your doctor right away if you become pregnant or if you stop using birth control for any reason during treatment with this medicine.

It is not known whether acetohydroxamic acid passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take acetohydroxamic acid?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take acetohydroxamic acid on an empty stomach, at least 1 hour before or 2 hours after a meal.

This medicine is usually taken every 6 to 8 hours. Follow your doctor's instructions.

Do not share this medicine with another person, even if they have the same symptoms you have. Acetohydroxamic acid is for use only in people with a certain type of bladder infection.

While using acetohydroxamic acid, you may need frequent blood and urine tests.

Take this medication for the full prescribed length of time, even if you have no symptoms of a bladder infection. Acetohydroxamic acid is not an antibiotic and will not treat a bacterial infection alone. Take your antibiotic medication as directed.

You may need to use acetohydroxamic acid for several years.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Uses of Acetohydroxamic Acid

  • It is used to lower the level of ammonia in your urine, which may help with some types of urinary infections.

What are some other side effects of Acetohydroxamic Acid?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Feeling nervous and excitable.
  • Anxiety.
  • Feeling tired or weak.
  • Upset stomach or throwing up.
  • Not hungry.
  • Shakiness.
  • Hair loss.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about acetohydroxamic acid, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about acetohydroxamic acid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using acetohydroxamic acid.

Review Date: October 4, 2017

Warnings

Contraindications

Hypersensitivity

Pts. amenable to definitive surgery & antimicrobial agents, infection by non-urease producing organisms, urinary infections controlled by culture-specific antimicrobials, severe renal impairment (CrCl <20 mL/min &/or serum creatinine>2.5 mg/dL [221 umol/L]), inadequate contraception (females), pregnancy

Cautions

Always use with appropriate antimicrobial treatment

Potential teratogen

Pregnancy & Lactation

Pregnancy Category: X

Lactation: excretion in breast milk unknown/not recommended

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

Pharmacology

Mechanism of Action

Inhibits bacterial urease, decreasing ammonia production

Does not acidify urine or have direct antibacterial effect

Pharmacokinetics

Absorption: Well-absorbed

Peak Plasma Time: 15 min -1 hr

Excretion: Urine (55% of oral dose unchanged)

Patient Handout

Print without Office InfoPrint with Office Info
(web3)