Adapalene and Benzoyl Peroxide

Name: Adapalene and Benzoyl Peroxide

What do I need to tell my doctor BEFORE I take Adapalene and Benzoyl Peroxide?

  • If you have an allergy to adapalene, benzoyl peroxide, or any other part of adapalene and benzoyl peroxide.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

How is this medicine (Adapalene and Benzoyl Peroxide) best taken?

Use adapalene and benzoyl peroxide as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Do not take this medicine by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
  • Do not put on cuts, scrapes, eczema, or damaged skin.
  • Do not put on sunburned skin.
  • Wash your hands before and after use.
  • Clean affected part before use. Make sure to dry well.
  • Put a thin layer on the affected skin and rub in gently.
  • Do not use coverings (bandages, dressings, make-up) unless told to do so by the doctor.

What do I do if I miss a dose?

  • Put on a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not put on 2 doses or extra doses.

If OVERDOSE is suspected

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Gel, topical:

Epiduo: Adapalene 0.1% and benzoyl peroxide 2.5% (45 g)

Epiduo Forte: Adapalene 0.3% and benzoyl peroxide 2.5% (45 g)

Generic: Adapalene 0.1% and benzoyl peroxide 2.5% (45 g)

Brand Names U.S.

  • Epiduo
  • Epiduo Forte


There are no contraindications listed in the US labeling.

Canadian labeling: Hypersensitivity to adapalene, benzoyl peroxide, or any component of the formulation; application to areas of skin affected by eczema or seborrheic dermatitis


Topical: Apply a pea-sized amount for each area of the face and/or trunk (eg, forehead, chin, each cheek). Skin should be clean and dry before applying. For external use only; avoid applying to eyes, lips, and mucous membranes. Do not apply to cuts, abrasions, eczematous or sunburned skin.

Adverse Reactions

Also see individual agents.


Dermatologic: Local dryness (mild 10% to 41%; moderate 2% to 15%), stinging sensation of the skin (mild 7% to 41%; moderate 1% to 19%), localized erythema (mild 8% to 27%; moderate 2% to 20%)

Local: Local desquamation (mild 9% to 35%; moderate 1% to 17%)

1% to 10%:

Dermatologic: Xeroderma (14%), skin irritation (≤4%), contact dermatitis (3%), burning sensation of skin (≤2%), atopic dermatitis (1%), eczema (1%)

Local: Application site irritation (1%)

<1% (Limited to important or life-threatening): Constriction of the pharynx, eyelid edema, facial swelling, skin blister