Adenovirus Type 4 and Type 7 Vaccine Live Oral

Name: Adenovirus Type 4 and Type 7 Vaccine Live Oral

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  • Adenovirus type 4 and type 7 vaccine live oral contains live, unattenuated strains of human adenovirus type 4 and human adenovirus type 7 prepared in human diploid fibroblast cell cultures (strain WI-38) and is used to stimulate active immunity to adenovirus type 4 and type 7.1

  • Provided by the manufacturer as 2 separate enteric-coated tablets to be taken together: one tablet contains the adenovirus type 4 vaccine component and one tablet contains the adenovirus type 7 vaccine component.1 Following oral administration, the enteric-coated tablets pass through the stomach intact.1 The live adenoviruses are then released in the intestines where they replicate and induce active immunity in individuals with low or no preexisting neutralizing antibodies to adenovirus serotypes.1

  • Following single dose of adenovirus type 4 and type 7 vaccine live oral in US military recruits ≥17 years of age, 99.3% effective in preventing adenovirus type 4 febrile acute respiratory disease (ARD)1 11 and adenovirus type 4 and type 7 seroconversion rates are 94.5 and 93.8%, respectively.1 11 Duration of protection and persistence of circulating antibodies after a single dose of the vaccine not determined.5

  • Live vaccine virus is shed in the stools of vaccinees;1 14 fecal shedding can last for up to 28 days after vaccination.14 In one study, 27 or 60% of vaccinees shed adenovirus type 4 or type 7 vaccine virus, respectively, in their stools.1

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