Adrucil injection

Name: Adrucil injection

Why is this medication prescribed?

Fluorouracil is generally used in combination with other medications to treat colon cancer or rectal cancer (cancer that begins in the large intestine) that has gotten worse or spread to other parts of the body. Fluorouracil is used in combination with other medications to treat certain types of breast cancer after surgery to remove the tumor or radiation therapy. Fluorouracil is also used to treat cancer of the pancreas and stomach cancer. Fluorouracil is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in your body.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?

Fluorouracil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • loss of appetite
  • nausea
  • unusual tiredness or weakness
  • dizziness
  • headache
  • hair loss
  • dry and cracked skin
  • vision changes
  • eye that are teary or sensitive to light
  • redness, pain, swelling, or burning at the site where the injection was given
  • confusion

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • sores in the mouth and throat
  • diarrhea
  • vomiting
  • swelling, pain, redness, or peeling of skin on the palms and soles of the feet
  • fever, chills, sore throat, or other signs of an infection
  • hives
  • rash
  • itching
  • difficulty breathing or swallowing
  • nosebleeds
  • coughing up or vomiting blood or material that looks like coffee grounds
  • unusual bleeding or bruising
  • pink, red, or dark brown urine
  • red or tarry black bowel movements
  • chest pain

Fluorouracil may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include the following:

  • nausea
  • diarrhea
  • vomiting
  • fever, chills, sore throat, or other signs of an infection
  • unusual bleeding or bruising
  • bloody or black, tarry stools
  • coughing up or vomiting blood or material that looks like coffee grounds

What is Adrucil (fluorouracil injection)?

Fluorouracil is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Fluorouracil is used to treat cancer of the colon, rectum, breast, stomach, or pancreas.

Fluorouracil may also be used for purposes not listed in this medication guide.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Adrucil (fluorouracil injection) side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • signs of infection such as fever, chills, sore throat, flu symptoms;

  • white patches or sores inside your mouth or throat, or on your lips;

  • pale skin, easy bruising or bleeding (nosebleeds, bleeding gums, or any bleeding that will not stop);

  • weakness or fainting;

  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • coughing up blood or vomit that looks like coffee grounds;

  • watery diarrhea, ongoing or severe vomiting;

  • pain, redness, numbness, and peeling skin on your hands or feet;

  • numbness or tingling anywhere in your body, loss of muscle control; or

  • sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common side effects may include:

  • temporary hair loss;

  • mild to moderate nausea and vomiting, loss of appetite;

  • mild, itchy skin rash;

  • eye dryness, watering, or increased sensitivity to light; or

  • temporary loss of your fingernails or toenails.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Adrucil (fluorouracil injection)?

Tell your doctor about all other cancer medications you are receiving, especially leucovorin.

Other drugs may interact with fluorouracil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

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