Advanced Sleep Melatonin

Name: Advanced Sleep Melatonin

What should I discuss with my health care provider before taking Advanced Sleep Melatonin (melatonin)?

You should not use melatonin if you are allergic to it.

Before using melatonin, talk to your healthcare provider. You may not be able to use melatonin if you have certain medical conditions, especially:

  • diabetes;

  • depression;

  • a bleeding or blood clotting disorder such as hemophilia;

  • high or low blood pressure;

  • epilepsy or other seizure disorder; or

  • if you are using any medicine to prevent organ transplant rejection.

It is not known whether melatonin will harm an unborn baby. Do not use this product without medical advice if you are pregnant.

High doses of melatonin may affect ovulation, making it difficult for you to get pregnant.

It is not known whether melatonin passes into breast milk or if it could harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.

Do not give any herbal/health supplement to a child without medical advice.

Is Melatonin a Hormone?

Melatonin is a natural hormone when produced in the body (the endogenous hormone). Melatonin is not a vitamin. Melatonin supplements (exogenous hormone) are made synthetically and all products and strengths on the U.S. market are available without a prescription at the pharmacy, nutrition stores, and other retail shops.

Melatonin is most commonly used to:

  • help decrease jet lag
  • adjust sleep cycles in the blind (non 24-Hour Sleep Wake Disorder, or Non-24)
  • treat shift-work sleep disorders in people with alternating work schedules
  • for general insomnias

How Does Melatonin Work?

Natural melatonin is a highly lipid soluble hormone produced in the pineal gland in the brain. It is synthesized from the amino acid tryptophan and then released into the blood and cerebrospinal fluid, crossing the blood-brain barrier. It sends messages to the melatonin receptor agonist in the brain and other areas of the body to help control the sleep and wake cycles.

Does melatonin help you sleep? When taken as supplement, the function of melatonin is to mimic the effects of the natural hormone. Drowsiness generally occurs within 30 minutes after taking melatonin. However, taking melatonin right before bed may not be the best strategy for all sleep disorders. Ask your doctor about the best method of dosing melatonin. Melatonin does not work for everyone.

Melatonin for Jet Lag

  • Eastbound: If you are traveling east, say from the US to Europe, take melatonin after dark, 30 minutes before bedtime in the new time zone or if you are on the plane. Then take it for the next 4 nights in the new time zone, after dark, 30 minutes before bedtime. If drowsy the day after melatonin use, try a lower dose.
  • Westbound: If you are heading west, for example, from the US to Australia, a dose is not needed for your first travel night, but you then may take it for the next 4 nights in the new time zone, after dark, 30 minutes before bedtime. Melatonin may not always be needed for westbound travel.

Given enough time (usually 3 to 5 days), jet lag will usually resolve on its own, but this is not always optimal when traveling.

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking.

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