Aerrane Inhalation Anesthetic
Name: Aerrane Inhalation Anesthetic
- Aerrane Inhalation Anesthetic dosage
- Aerrane Inhalation Anesthetic drug
- Aerrane Inhalation Anesthetic action
- Aerrane Inhalation Anesthetic aerrane inhalation anesthetic dosage
Aerrane Inhalation Anesthetic Description
Each mL contains 99.9% isoflurane.
Some physical constants are:
|Molecular weight ||184.5 |
|Boiling point at 760 mmHg ||48.5°C (uncorr.) |
|Refractive i n d e x n 20/D||1.2990-1.3005 |
|Specific gravity 25°/25°C ||1.496 |
|Vapor pressure in mmHg**||20°C 238 |
|25°C 295 |
|30°C 367 |
|35°C 450 |
log10Pvap = A + B/T
where: A = 8.056
B = -1664.58
T = °C + 273.16 (Kelvin)
Partition coefficients at 37°C
|Water/gas ||0.61 |
|Blood/gas ||1.43 |
|Oil/gas ||90.8 |
|Partition coefficients at 25°C - rubber and plastic |
|Conductive rubber/gas ||62.0 |
|Butyl rubber/gas ||75.0 |
|Polyvinyl chloride/gas ||110.0 |
|Polyethylene/gas ||~2.0 |
|Polyurethane/gas ||~1.4 |
|Polyolefin/gas ||~1.1 |
|Butyl acetate/gas ||~2.5 |
|Purity by gas chromatography ||>99.9% |
|Lower limit of flammability in oxygen |
or nitrous oxide at 9 joules/sec. and 23°C
|Lower limit of flammability in |
oxygen or nitrous oxide at
900 joules/sec. and 23°C
|Greater than useful |
MAC (Minimum Alveolar Concentration) is 1.31% in horses1 and 1.28 in dogs6.
Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base stability. Isoflurane does not decompose in the presence of soda lime (at normal operating temperatures), and does not attack aluminum, tin, brass, iron or copper.
AERRANE (isoflurane, USP) is used for induction and maintenance of general anesthesia in horses and dogs.
Increasing depth of anesthesia with AERRANE (isoflurane, USP) may increase hypotension and respiratory depression. The electroencephalographic pattern associated with deep anesthesia is characterized by burst suppression, spiking, and isoelectric periods.4
Since levels of anesthesia may be altered easily and rapidly, only vaporizers producing predictable percentage concentrations of isoflurane should be used (see DOSAGE AND ADMINISTRATION).
The action of nondepolarizing relaxants is augmented by isoflurane. Less than the usual amounts of these drugs should be used. If the usual amounts of nondepolarizing relaxants are given, the time for recovery from myoneural blockade will be longer in the presence of isoflurane than in the presence of other commonly used anesthetics. Not for use in horses intended for food.
Aerrane Inhalation Anesthetic Dosage and Administration
Caution: Operating rooms should be provided with adequate ventilation to prevent the accumulation of anesthetic vapors.
Premedication: A premedication regimen, which may be employed depending upon the patient status, to avert excitement during induction, might include an anticholinergic, a tranquilizer, a muscle relaxant, and a short-acting barbiturate.
Inspired Concentration: The delivered concentration of AERRANE (isoflurane, USP) should be known. Isoflurane may be vaporized using a flow-through vaporizer specifically calibrated for isoflurane. Vaporizers delivering a saturated vapor which then is diluted (e.g., Vernitrol® Vaporizer) also may be used. The delivered concentration from such a vaporizer may be calculated using the formula:
Isoflurane contains no stabilizer. Nothing in the drug product alters calibration or operation of these vaporizers.
Horses: Inspired concentrations of 3.0 to 5.0% isoflurane alone with oxygen following a barbiturate anesthetic induction are usually employed to induce surgical anesthesia
in the horse.
Dogs: Inspired concentrations of 2.0 to 2.5% isoflurane alone with oxygen following a barbiturate anesthetic induction are usually employed to induce surgical anesthesia in the dog.
These concentrations can be expected to produce surgical anesthesia in 5 to 10 minutes.
Maintenance: The concentration of vapor necessary to maintain anesthesia is much less than that required to induce it.
Horses: Surgical levels of anesthesia in the horse may be sustained with a 1.5 to 1.8% concentration of isoflurane in oxygen.
Dogs: Surgical levels of anesthesia in the dog may be sustained with a 1.5 to 1.8% concentration of isoflurane in oxygen.
The level of blood pressure during maintenance is an inverse function of isoflurane concentration in the absence of other complicating problems. Excessive decreases, unless related to hypovolemia, may be due to depth of anesthesia and in such instances may be corrected by lightening the level of anesthesia. Recovery from isoflurane anesthesia is typically uneventful.2
How is Aerrane Inhalation Anesthetic Supplied
AERRANE (isoflurane, USP) is packaged in 100 mL and 250 mL
100 mL - NDC 10019-773-40
250 mL - NDC 10019-773-60
StorageStore at room temperature 15°-30°C (59°-86°F).
Package labeling - principal display panel
For Use In Horses and Dogs
Caution: Federal law restricts this drug
to use by or on order of
a licensed veterinarian.
[NADA 135-773, Approved by FDA]
Baxter Healthcare Corporation
Deerfield, IL 60015 USA
A nonflammable, nonexplosive
Each mL container 99.9% isofurane.
Caution:Operating rooms should be pro-
vided with adequate ventilation to prevent the
accumulation of anesthetic vapors.
Store at room temperature 15°-30°C
IMPORTANT: See package insert for dosage
and directions for use.
To report adverse reaction or obtain MSDS,
call 1 800 ANA DRUG (1-800-262-3784)
Baxter and Aerrane are trademarks of Baxter
Not for Use
N3 10019 77340 7
6 x 100 mL Bottles
For use in Horses and Dogs
Store at room temperature 15°-30°C (59°-86°F).
Exp 10 2007
(17) 071000(10) A111A111
(01) 5 0310019 77340 2(30) 0006
Mfd. for Baxter Healthcare Corporation, Deerfield, IL 60015 USA
|Labeler - BAXTER HEALTHCARE CORPORATION (005083209)|
|BAXTER HEALTHCARE SA, dba Baxter Healthcare of Puerto Rico||154731033||manufacture|