- Antizol side effects
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Fomepizole Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregiver right away if you have:
- skin rash, bruising, severe tingling, numbness, pain, muscle weakness.
- severe nausea, severe dizziness or spinning sensation; or
- a light-headed feeling, like you might pass out.
Common side effects may include:
- dizziness, drowsiness;
- nausea; or
- unpleasant or metallic taste in your mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Other drugs may interact with fomepizole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Jazz Pharmaceuticals, Inc.
Paladin Laboratories (usa) Inc
What happens if I miss a dose?
Because you will receive fomepizole in a clinical setting, you are not likely to miss a dose.
Interactions for Antizol
Metabolized by mixed-function oxidases (cytochrome P-450 system).b Potent inducer of CYP-mediated drug elimination; induces own metabolism.a b
Drugs Affecting Hepatic Microsomal Enzymes
Inhibitors or inducers of CYP isoenzymes: Potential pharmacokinetic interaction; however, no studies to date.b
Decreased elimination rate of fomepizole and alcohol (possibly due to inhibition of alcohol dehydrogenase)1 2 4 5 7 22 23 24 25 26 33 b
Immediately and completely bioavailable following IV administration.a
Rapidly distributes to total body water following IV infusion.b
Not known whether fomepizole is distributed into milk.b
Metabolized in the liver.b
Induces own metabolism; elimination rate increases after about 30–40 hours.b
Excreted in urine mainly as metabolites; only 1–3.5% of administered dose excreted in urine as unchanged drug. b
Fomepizole is dialyzable.1 25
Not determined, but varies with dose.b
Pharmacokinetics not studied in patients with hepatic or renal impairment or in geriatric patients.1
What are some things I need to know or do while I take Antizol?
- Tell all of your health care providers that you take Antizol. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- You will need to have your heart checked before starting this medicine and while taking it. This includes an ECG. Talk with your doctor.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Antizol while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How do I store and/or throw out Antizol?
- If you need to store Antizol at home, talk with your doctor, nurse, or pharmacist about how to store it.
Antizol® should not be administered to patients with a documented serious hypersensitivity reaction to Antizol® or other pyrazoles.
Where can i get more information?
Your doctor or pharmacist can provide more information about fomepizole.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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For Healthcare Professionals
Applies to fomepizole: intravenous solution
The most common adverse events were headache, nausea, dizziness, increased drowsiness, and bad taste/metallic taste.[Ref]
Very common (10% or more): Nausea (11%)
Common (1% to 10%): Abdominal pain, vomiting, diarrhea, dyspepsia, heartburn[Ref]
Very common (10% or more): Headache (14%)
Common (1% to 10%): Dizziness, increased drowsiness, bad taste/metallic taste, lightheadedness, seizure, agitation, feeling drunk, vertigo, nystagmus, anxiety, "felt strange", decreased environmental awareness, abnormal smell, roar in ear[Ref]
Common (1% to 10%): Fever, multiorgan system failure, hangover, speech/visual disturbances[Ref]
Common (1% to 10%): Sinus bradycardia/bradycardia, phlebosclerosis, tachycardia, phlebitis, shock, hypotension[Ref]
Common (1% to 10%): Eosinophilia/hypereosinophilia, lymphangitis, disseminated intravascular coagulation, anemia[Ref]
Common (1% to 10%): Transient transaminitis[Ref]
Common (1% to 10%): Pain during injection, inflammation at injection site, application site reaction[Ref]
Common (1% to 10%): Anuria[Ref]
Common (1% to 10%): Hiccups, pharyngitis[Ref]
Common (1% to 10%): Transient blurred vision[Ref]
Common (1% to 10%): Facial flush, rash[Ref]
Common (1% to 10%): Lumbalgia/backache[Ref]
Common (1% to 10%): Decreased appetite
Some side effects of Antizol may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.