Chymopapain (Injection Route)

Name: Chymopapain (Injection Route)

Descriptions

Chymopapain is injected directly into a herniated ("slipped'') disk in the spine to dissolve part of the disk and relieve the pain and other problems caused by the disk pressing on a nerve. Before you receive chymopapain, you will be given an anesthetic (either a general anesthetic to put you to sleep or a local anesthetic).

Very rarely, use of chymopapain may cause serious side effects, including paralysis of the legs or death. Another dangerous side effect of chymopapain injection is a severe allergic reaction called anaphylaxis. This side effect occurs in less than 1% of the patients receiving the medicine, but it occurs more often in women than in men. Before receiving chymopapain, you should discuss its use, and the possibility of anaphylaxis or other serious side effects, with your doctor.

Chymopapain injections are given only in a hospital, usually in an operating room, by your surgeon.

This medicine was available only with your doctor's prescription.

The sale and distribution of chymopapain was discontinued in the US in January 27, 2003 .

This product is available in the following dosage forms:

  • Powder for Solution

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergic reaction to papaya or
  • Previous chymopapain injection—Increased risk of serious allergic reactions.
  • Diseases of the back (spine), muscles, or nerves or
  • High blood pressure (hypertension) or
  • Stroke or bleeding in the brain (or if any member of your family has ever had these problems) or
  • Surgery of the back—The chance of side effects may be increased.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

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