Ezetimibe Simvastatin

Name: Ezetimibe Simvastatin

Vytorin Interactions

You also shouldn't take Vytroin if you are taking certain other medications, as they may increase your risk of developing muscular disease (myopathy). These drugs include:

  • Anti-fungal drugs, including itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend)
  • HIV protease inhibitors, including indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), saquinavir (Fortovase), tipranavir (Aptivus), and atazanavir (Reyataz)
  • Hepatitis C virus protease inhibitors boceprevir (Victrelis) and telaprevir (Incivek)
  • Certain antibiotics, such as erythromycin (E-Mycin, Eryc), clarithromycin (Biaxin), and telithromycin (Ketek)
  • Antidepressant nefazodone (Serzone)
  • Medications containing the HIV drug, cobicistat
  • Cholestol-lowering gemfibrozil (Lopid)
  • Immunosuppressive drug cyclosporine (Restasis)
  • Synthetic steroid danazol (Danocrine)

It's important to tell your doctor about any prescription, non-prescription, over-the-counter, illegal, and recreational drugs you're taking, as well as any vitamins and supplements.

In addition to the drugs listed above, Vytorin may interact with:

  • Cholesterol-lowering fibrates, including fenofibrate (Tricor, Lofibra), and gemfibrozil (Lopid)
  • Amiodarone (Cordarone) and verapamil (Calan, Covera-HS)
  • Cholestyramine (Questran)
  • Digoxin (Lanoxin)
  • Coumarin anticoagulants, including warfarin (Coumadin, Jantoven)
  • Propranolol (Inderol)
  • Niacin (vitamin B3)
  • Colchicine

Vytorin and Alcohol

Drinking excessive alcohol while taking Vytorin may increase your risk of liver damage and raise your triglyceride levels.

Vytorin and Grapefruit

While taking Vytorin, you should not drink more than one quart of grapefruit juice per day, as this may increase your risk of myopathy.

Ezetimibe & Simvastatin Precautions

Ezetimibe/simvastatin includes a statin medication called simvastatin. Statin medications carry a rare but serious risk of:

  • liver damage
  • memory loss or confusion
  • increase in blood sugar levels (hyperglycemia)
  • type 2 diabetes
  • immune-mediated muscle breakdown

Certain statins can increase risk of muscle weakness as well.  It is important to consult your physician to discuss the benefits and risks associated with using this medication.

Do not take ezetimibe/simvastatin:

  • If you are allergic to ezetimibe or simvastatin, or to the inactive ingredients.
  • If you have active liver disease or repeated blood tests indicating possible liver problems.
  • If you are pregnant, or think you may be pregnant, or planning to become pregnant or breastfeeding.
  • If you are a woman of childbearing age, you should use an effective method of birth control to prevent pregnancy while using ezetimibe/simvastatin.

Ezetimibe/simvastatin has not been studied in children under 10 years of age.

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