How is this medicine (Megatope) best taken?
Use Megatope as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into a vein.
- A drug to protect the thyroid gland will be given to you. Take it as you have been told. If this is not done, the chance of thyroid cancer later in life may be raised. Talk with your doctor.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some other side effects of Megatope?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Federal (USA) law prohibits dispensing without prescription
Iodine 131 decays by beta and gamma emissions with a physical half-life of 8.08 days.1
Photons that are useful for detection and imaging studies are listed in Table 1.
The specific gamma ray constant for iodine 131 is 2.2 R/hour-millicurie at 1 cm. The
first half-value layer is 0.24 cm lead (Pb). A range of values for the relative attenuation
of the radiation emitted by this radionuclide that result from interposition of various
thicknesses of Pb is shown in Table 2. To facilitate control of the radiation exposure
from this radionuclide, the use of a 2.55 cm thickness of Pb will attenuate the radiation
emitted by a factor of about 1,000.
In the use of any radioactive material, care should be taken to insure minimum
radiation exposure to the patient and occupational workers consistent with proper
Radiopharmaceuticals should be used only by physicians who are qualified by
training and experience in the safe use and handling of radionuclides and whose
experience and training have been approved by the appropriate government agency
authorized to license the use of radionuclides.
Impairment of Fertility
No long-term animal studies have been performed to evaluate carcinogenic potential
or whether iodinate I 131 albumin affects fertility in males and females.
Pregnancy Category C
Animal reproduction studies have not been conducted with Iodinated I 131 Albumin
Injection. It is also not known whether this agent can cause fetal harm when adminis-
tered to a pregnant woman or can affect reproduction capacity. Iodinated I 131
Albumin injection should be administered to a pregnant woman only if clearly
Ideally, examinations using radiopharmaceuticals, especially those elective in
nature, of a woman of childbearing capability should be performed during the first few
(approximately 10) days following the onset of menses.
Since iodine 131 is excreted in human milk during lactation, formula feedings should
be substituted for breast feedings.
Safety and effectiveness in children have not been established.
Although the immunological properties of albumin human are believed to be virtually
unaltered by the iodination process, there is a theoretical possibility that allergic
reactions may occur in patients receiving additional doses a number of weeks after an
iodinated i-131 albumin injection, solution
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