Name: Minoxidil (Systemic)
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Generic: 2.5 mg, 10 mg
- Vasodilator, Direct-Acting
Onset of Action
Hypotensive: ~30 minutes; Peak effect: 2 to 3 hours
Use Labeled Indications
Hypertension: Treatment of hypertension that is symptomatic or associated with target organ damage, and is not manageable with maximum therapeutic doses of a diuretic plus 2 other antihypertensives. Use in milder degrees of hypertension is not recommended because the benefit-risk ratio in such patients has not been defined.
Note: According to the Eighth Joint National Committee (JNC 8) guidelines, minoxidil is not recommended for the initial treatment of hypertension (James, 2013).
Blood pressure, standing and sitting/supine; signs/symptoms of pericardial effusion; fluid and electrolyte balance and body weight should be monitored. Any tests that are abnormal at the time of initiation (including, renal function tests, ECG, echocardiogram, chest x-ray) should be repeated initially every 1 to 3 months then every 6 to 12 months once stable.