Moclobemide

Name: Moclobemide

Getting the most from your treatment

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
  • Some people who take moclobemide can be sensitive to a substance called tyramine which is present in some foods and alcoholic drinks. You should avoid eating large amounts of food such as mature cheese, yeast extracts such as Marmite®, Oxo® and Bovril®, and fermented soya bean extract (an ingredient in some Chinese food).
  • When you first start taking moclobemide, you may have thoughts about harming yourself or ending your life. These thoughts can be associated with your condition. It is very important that you tell your doctor about this if it happens.
  • Continue to take moclobemide unless your doctor tells you otherwise. Stopping treatment suddenly can sometimes cause problems and your doctor will probably want you to reduce your dose gradually if this becomes necessary. Your doctor may ask you to carry on taking moclobemide even after you feel better. This is normal and helps to prevent your symptoms from recurring.
  • Check with a pharmacist before you buy or take any other medicines, to make sure that they are safe to take with moclobemide. Some commonly used cough and cold remedies and some painkillers must not be taken with moclobemide.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking moclobemide.

Moclobemide Drug Class

Moclobemide is part of the drug class:

  • Monoamine oxidase A inhibitors

Moclobemide Interactions

This is not a complete list of Moclobemidedrug interactions. Ask your doctor or pharmacist for more information.

Uses For moclobemide

Moclobemide is a monoamine oxidase (MAO) inhibitor used to treat certain types of mental depression. It works by blocking the action of a chemical substance known as monoamine oxidase (MAO) in the nervous system.

Although moclobemide is very effective for certain patients, it may also cause some unwanted reactions if taken the wrong way. It is very important to avoid certain beverages and medicines while you are using moclobemide. Your doctor may provide a list as a reminder of which products you should avoid.

moclobemide is available only with your doctor's prescription.

Before Using moclobemide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For moclobemide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to moclobemide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on moclobemide have been done only in adult patients, and there is no specific information comparing use of moclobemide in children with use in other age groups.

Geriatric

Older adults are especially sensitive to the effects of moclobemide. This may increase the chance of side effects during treatment. Dizziness or lightheadedness may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to these effects.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking moclobemide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using moclobemide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amitriptyline
  • Amoxapine
  • Amphetamine
  • Apraclonidine
  • Atomoxetine
  • Benzphetamine
  • Brimonidine
  • Bupropion
  • Carbamazepine
  • Carbidopa
  • Carbinoxamine
  • Citalopram
  • Clomipramine
  • Codeine
  • Cyclobenzaprine
  • Cyproheptadine
  • Desipramine
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexfenfluramine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan
  • Diethylpropion
  • Dothiepin
  • Doxepin
  • Doxylamine
  • Escitalopram
  • Fenfluramine
  • Fluoxetine
  • Fluvoxamine
  • Guanadrel
  • Guanethidine
  • Hydroxytryptophan
  • Imipramine
  • Isometheptene
  • Levodopa
  • Levomethadyl
  • Levomilnacipran
  • Lisdexamfetamine
  • Lofepramine
  • Maprotiline
  • Mazindol
  • Meperidine
  • Methamphetamine
  • Methotrimeprazine
  • Methyldopa
  • Methylphenidate
  • Milnacipran
  • Mirtazapine
  • Nefopam
  • Nortriptyline
  • Opicapone
  • Opipramol
  • Paroxetine
  • Phendimetrazine
  • Phenmetrazine
  • Phentermine
  • Phenylalanine
  • Protriptyline
  • Pseudoephedrine
  • Reserpine
  • Safinamide
  • Selegiline
  • Sertraline
  • Sibutramine
  • Sumatriptan
  • Tapentadol
  • Tetrabenazine
  • Tramadol
  • Trazodone
  • Trimipramine
  • Tryptophan
  • Venlafaxine
  • Vilazodone
  • Vortioxetine

Using moclobemide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfentanil
  • Altretamine
  • Atropine
  • Buprenorphine
  • Buspirone
  • Butorphanol
  • Cilostazol
  • Clovoxamine
  • Difenoxin
  • Dihydrocodeine
  • Diphenoxylate
  • Dolasetron
  • Droperidol
  • Ethchlorvynol
  • Femoxetine
  • Fentanyl
  • Frovatriptan
  • Granisetron
  • Guarana
  • Hydrocodone
  • Hydromorphone
  • Iobenguane I 123
  • Kava
  • Levorphanol
  • Licorice
  • Ma Huang
  • Mate
  • Methadone
  • Methylene Blue
  • Midodrine
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Naratriptan
  • Nebivolol
  • Nefazodone
  • Oxycodone
  • Oxymetazoline
  • Oxymorphone
  • Palonosetron
  • Pentazocine
  • Reboxetine
  • Remifentanil
  • St John's Wort
  • Sufentanil
  • Tyrosine
  • Valbenazine
  • Ziprasidone

Using moclobemide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Chlorpropamide
  • Ginseng
  • Glimepiride
  • Glipizide
  • Glyburide
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glargine, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Metformin
  • Nateglinide
  • Repaglinide
  • Tolazamide
  • Tolbutamide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using moclobemide with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use moclobemide, or give you special instructions about the use of food, alcohol, or tobacco.

  • Avocado
  • Bitter Orange

Other Medical Problems

The presence of other medical problems may affect the use of moclobemide. Make sure you tell your doctor if you have any other medical problems, especially:

  • Hypertension—May make this condition worse.
  • Liver disease—Effects may be increased because of slower removal of the medicine from the body.

Precautions While Using moclobemide

When taken with certain drinks or other medicines, moclobemide and other monoamine oxidase inhibitors can cause very dangerous reactions, such as sudden high blood pressure (also called hypertensive crisis). To avoid such reactions, follow these rules of caution:

  • Do not drink excessive amounts of alcohol.
  • Do not take any other medicine unless approved or prescribed by your doctor. This especially includes nonprescription (over-the-counter [OTC]) medicine, such as medicine for colds (including nose drops or sprays), cough, hay fever, and appetite control; "stay awake" products; or products that make you sleepy.

Check with your doctor immediately if you experience any combination of the following symptoms: severe, throbbing headache that starts at the back of the head and radiates forward; stiff neck; fast or racing heartbeat; pounding, irregular, or slow heartbeat. These may be symptoms of a serious side effect that should have a doctor's attention.

Do not stop taking moclobemide without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position suddenly. Getting up slowly may help. When you get up from lying down, sit on the edge of the bed with your feet dangling for 1 or 2 minutes, then stand up slowly. If the problem continues or gets worse, check with your doctor.

moclobemide may cause blurred vision or make some people drowsy or less alert than they are normally. Make sure you know how you react to moclobemide before you drive, use machines, or do anything else that could be dangerous if you are unable to see well or are not alert.

Before having any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using moclobemide or have used it within the past 2 weeks. Taking moclobemide together with medicines that are used during surgery, dental, or emergency treatments may increase the risk of serious side effects.

After you stop using moclobemide, you must continue to exercise caution for at least 2 weeks with your foods, drinks, and other medicines, since these items may continue to react with moclobemide.

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