Potassium Acetate

Name: Potassium Acetate

Side effects

Adverse reactions involve the possibility of potassium intoxication.The signs and symptoms of potassium intoxication include paresthesias of the extremities, flaccid paralysis, listlessness,mental confusion, weakness and heaviness of the legs,hypotension, cardiac arrhythmias, heart block, electrocardiographic abnormalities such as disappearance of P waves, spreading and slurring of the QRS complex with development of a biphasic curve and cardiac arrest. See WARNINGS and PRECAUTIONS.

Drug Abuse And Dependence

None known.

Overdose

In the event of overdosage, discontinue infusion containing potassium acetate immediately and institute corrective therapy as indicated to reduce elevated serum potassium levels and restore acid-base balance if necessary. See WARNINGS, PRECAUTIONS and ADVERSE REACTIONS.

Potassium Acetate and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Potassium Acetate falls into category C:

In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

OR

There are no well-controlled studies that have been done in pregnant women. Potassium Acetate should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

OR

No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Potassium Acetate should be given to a pregnant woman only if clearly needed.

What are some things I need to know or do while I take Potassium Acetate?

  • Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • You may need to have an ECG checked before starting potassium acetate and while taking it. Talk with your doctor.
  • If you are taking a salt substitute that has potassium, potassium-sparing diuretics, or potassium, talk with your doctor.
  • This medicine may contain aluminum. There is a chance of aluminum toxicity if you are on this medicine for a long time. The risk is greater if you have kidney problems. The risk is also higher in premature infants. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using potassium acetate while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Potassium Acetate - Clinical Pharmacology

Potassium is found in low concentration in plasma and extracellular fluids. It is the chief cation of body cells, and is concerned with the maintenance of the body fluid composition and electrolyte balance. The major amount of potassium is excreted in the urine. Therefore, the kidney normally determines potassium balance.

The acetate ion is completely metabolized in the body, providing a source of hydrogen ion acceptors.

Contraindications

Potassium Acetate Injection, USP, administration is contraindicated in diseases where high potassium levels may be encountered.

Package label.principal display panel

PRINCIPLE DISPLAY PANEL – 20 mL Container

NDC 0517-2053-25

Potassium Acetate INJECTION, USP

40 mEq/20 mL

(2 mEq/mL)

20 mL SINGLE DOSE VIAL

FOR IV USE AFTER DILUTION

Rx Only

AMERICAN REGENT, INC.

SHIRLEY, NY 11967

Potassium Acetate 
Potassium Acetate injection, solution
Product Information
Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:0517-2053
Route of Administration INTRAVENOUS DEA Schedule     
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
Potassium Acetate (POTASSIUM CATION) Potassium Acetate 196 mg  in 1 mL
Inactive Ingredients
Ingredient Name Strength
ACETIC ACID  
WATER  
Packaging
# Item Code Package Description
1 NDC:0517-2053-25 25 VIAL, SINGLE-DOSE (VIAL) in 1 TRAY
1 20 mL in 1 VIAL, SINGLE-DOSE
Marketing Information
Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
Unapproved drug other 09/30/1990
Labeler - American Regent, Inc. (622781813)
Revised: 07/2012   American Regent, Inc.

Dosing Adult

IV doses should be incorporated into the patient's maintenance IV fluids, intermittent IV potassium administration should be reserved for severe depletion situations and requires ECG monitoring; doses listed as mEq of potassium

Treatment of hypokalemia: IV: 40-100 mEq/day

IV intermittent infusion (must be diluted prior to administration):

5-10 mEq/dose (maximum: 40 mEq/dose) to infuse over 2-3 hours (maximum: 40 mEq over 1 hour)

Note: Continuous cardiac monitor recommended for rates >0.5 mEq/kg/hour

Potassium dosage/rate of infusion guidelines:

Serum potassium >2.5 mEq/L: Maximum infusion rate: 10 mEq/hour; maximum concentration: 40 mEq/L; maximum 24-hour dose: 200 mEq

Serum potassium <2.5 mEq/L: Maximum infusion rate: 40 mEq/hour; maximum concentration: 80 mEq/L; maximum 24-hour dose: 400 mEq

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