Promethazine Injection, Intravenous
Name: Promethazine Injection, Intravenous
- Promethazine Injection, Intravenous brand name
- Promethazine Injection, Intravenous dosage
- Promethazine Injection, Intravenous dosage forms
- Promethazine Injection, Intravenous works by
- Promethazine Injection, Intravenous effects of
- Promethazine Injection, Intravenous the effects of
- Promethazine Injection, Intravenous injection
- Promethazine Injection, Intravenous side effects
- Promethazine Injection, Intravenous drug
Commonly used brand name(s)
In the U.S.
- Antinaus 50
Available Dosage Forms:
Therapeutic Class: Gastrointestinal Agent
Pharmacologic Class: Phenothiazine
Chemical Class: Aliphatic
Uses For promethazine
Promethazine injection is used to relieve or prevent some types of allergy or allergic reactions. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. It can sometimes close up the bronchial tubes (air passages of the lungs) and make breathing difficult.
Promethazine is also used to prevent and control motion sickness, nausea, vomiting, and dizziness. In addition, it may be used to help people go to sleep and control their pain or anxiety before or after surgery or other procedures.
Promethazine may also be used for other conditions as determined by your doctor.
promethazine is only available with your doctor's prescription.
Before Using promethazine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For promethazine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to promethazine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of promethazine injection in the pediatric population. Use of promethazine injection is not recommended in children younger than 2 years of age because of the increased risk of respiratory depression. Caution should be used when promethazine is given to children 2 years of age and older.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of promethazine injection in the elderly. However, elderly patients may be more sensitive to the side effects of promethazine than in younger adults, and are more likely to have age-related heart or blood vessel disease or prostate problems, which may require an adjustment in the dose for patients receiving promethazine injection.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving promethazine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using promethazine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Sodium Oxybate
Using promethazine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Morphine Sulfate Liposome
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
Using promethazine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aminolevulinic Acid
- Belladonna Alkaloids
- Betel Nut
- Evening Primrose
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of promethazine. Make sure you tell your doctor if you have any other medical problems, especially:
- Brain disease or injury or
- Breathing or lung problems (e.g., asthma, COPD) or
- Comatose state (unconscious) or
- Reye's syndrome or
- Sleep apnea, history of—Should not be used in patients with these conditions.
- Bladder-neck blockage or
- Bone marrow disease (e.g., agranulocytosis, leukopenia) or
- Enlarged prostate or
- Glaucoma, narrow-angle or
- Heart or blood vessel disease or
- Intestinal blockage or
- Liver disease (including jaundice) or
- Neuroleptic malignant syndrome, history of or
- Respiratory depression (very slow breathing) or
- Stomach ulcer or
- Urinary tract blockage or difficult urination—Use with caution. May make these conditions worse.
- Seizure disorders—promethazine may increase the chance of seizures especially in patients who are also using narcotic or anesthetic medicines.
Proper Use of promethazine
A nurse or other trained health professional will give you promethazine. promethazine is given as a shot into a muscle or into a vein.
Your doctor will give you a few doses of promethazine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.
Precautions While Using promethazine
It is very important that your doctor check the progress of you or your child at regular visits to make sure promethazine is working properly. Blood tests may be needed to check for unwanted effects.
promethazine contains sodium metabisulfite. Make sure your doctor knows if you or your child have had an allergic reaction to sulfite in the past.
Check with your doctor right away if you or your child have burning, persistent or worsening pain at the injection site; or any involuntary muscle movements after receiving promethazine.
promethazine may affect blood sugar levels. If you or your child notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.
promethazine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, antidepressants, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you or your child are taking promethazine.
Check with your doctor right away if you or your child have pale or blue lips, fingernails, or skin; difficult or troubled breathing; irregular, fast, slow, or shallow breathing; or shortness of breath. These could be signs of a condition called respiratory depression.
promethazine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to promethazine before you drive, use machines, or do anything else that could be dangerous if you are not alert.
Promethazine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you or your child think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
Check with your doctor right away if you or your child are having convulsions, difficulty in breathing, fast heartbeat, high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).
Check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a liver problem.
Before you have any medical tests, tell the medical doctor in charge that you or your child are receiving promethazine. The results of some tests may be affected by promethazine.
promethazine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.
promethazine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.