Thalitone

Name: Thalitone

Which drugs or supplements interact with chlorthalidone?

Chlorthalidone can lower blood potassium and magnesium levels because both potassium and magnesium are lost in the urine. This is especially true in patients who are also taking another class of diuretics, called loop diuretics which includes furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex). Low potassium and magnesium levels can lead to abnormal heart rhythms, especially in patients taking digoxin (Lanoxin).

Chlorthalidone reduces the kidney's ability to eliminate lithium (Eskalith, Lithobid) in the urine. As a result, patients taking chlorthalidone at the same time as drugs containing lithium may develop high levels of lithium and lithium toxicity.

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin), naproxen (Naprosyn), and nabumetone (Relafen) can reduce the effectiveness of chlorthalidone though the reason for this is not clear. Blood sugar levels can be elevated by thiazide diuretics. Patients with diabetes may need to adjust the doses of of medications they are taking for treating diabetes.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of chlorthalidone in the pediatric population. Safety and efficacy have not been established.

Thalitone Overview

Thalitone is a prescription medication used to treat high blood pressure and fluid retention caused by congestive heart failure and other conditions. Thalitone belongs to a group of drugs called diuretics ("water pills") which help the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood.

This medication comes in tablet form and is usually taken once daily, with or without food. 

Common side effects include stomach pain, vomiting, and diarrhea. Thalitone can also cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.

Thalitone Precautions

Serious side effects can occur including:

  • worsening of kidney disease
  • worsening of gout
  • worsening of systemic lupus erythematosus (SLE). Medications like Lozol have exacerbated SLE.
  • increased blood glucose levels
  • electrolyte imbalance. This medication may affect electrolytes including sodium and potassium. Your doctor will check these levels using a blood test. Warning signs of electrolyte imbalance include:
    • dry mouth
    • thirst
    • weakness
    • lack of energy
    • drowsiness
    • restlessness
    • muscle pains or cramps
    • muscle fatigue
    • low blood pressure
    • decreased urination
    • fast heart rate
    • nausea and vomiting
  • impaired liver function. This medication should be used with caution in patients with liver disease.

Do not take Thalitone if you:

  • are allergic to Thalitone or any other ingredient of Thalitone
  • have severe kidney disease

 

What is Thalitone (chlorthalidone)?

Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Chlorthalidone treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. Chlorthalidone is also used to treat high blood pressure (hypertension).

Chlorthalidone may also be used for purposes not listed in this medication guide.

Thalitone (chlorthalidone) side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • little or no urination;

  • severe pain in your upper stomach spreading to your back;

  • pale or yellowed skin, dark colored urine, fever, easy bruising or bleeding;

  • high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, confusion, lack of energy, or tired feeling;

  • low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;

  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or

  • other signs of an an electrolyte imbalance--dry mouth, thirst, nausea, vomiting, drowsiness, feeling weak or restless, muscle pain, fast heart rate, seizure (convulsions).

Common side effects may include:

  • dizziness, spinning sensation;

  • nausea, vomiting, diarrhea, constipation;

  • muscle spasm; or

  • impotence, sexual problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Thalitone (chlorthalidone)?

Taking this medicine with other drugs that make you light-headed can worsen this effect. Ask your doctor before taking chlorthalidone with a cold or allergy medicine, sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • other blood pressure medications;

  • digoxin, digitalis;

  • lithium;

  • insulin or oral diabetes medicine; or

  • steroid medicine.

This list is not complete. Other drugs may interact with chlorthalidone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Introduction

Diuretic and antihypertensive agent, structurally and pharmacologically similar to thiazides.

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Chlorthalidone

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Tablets

15 mg

Thalitone

Monarch

25 mg*

Chlorthalidone Tablets

50 mg*

Chlorthalidone Tablets

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Atenolol and Chlorthalidone

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Tablets

Atenolol 50 mg and Chlorthalidone 25 mg*

Atenolol and Chlorthalidone Tablets

Tenoretic

AstraZeneca

Atenolol 100 mg and Chlorthalidone 25 mg*

Atenolol and Chlorthalidone Tablets

Tenoretic

AstraZeneca

Clonidine Hydrochloride and Chlorthalidone

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Tablets

0.1 mg Clonidine Hydrochloride and Chlorthalidone 15 mg

Clorpres (scored)

Mylan

0.2 mg Clonidine Hydrochloride and Chlorthalidone 15 mg

Clorpres (scored)

Mylan

0.3 mg Clonidine Hydrochloride and Chlorthalidone 15 mg

Clorpres (scored)

Mylan

How supplied

White, kidney-shaped, compressed tablets coded M/024 containing 15 mg of chlorthalidone in bottles of 100 (NDC 61570-024-01).

Storage: Store below 30°C (86°F).

Rx Only

Prescribing Information as of January 2004.

Distributed by:

Monarch Pharmaceuticals, Inc., Bristol, TN 37620

(A wholly owned subsidiary of King Pharmaceuticals, Inc.)

Manufactured by:

King Pharmaceuticals, Inc., Bristol, TN 37620

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