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Trental is a prescription medication used to reduce the symptoms of intermittent claudication (pain in the legs when walking due to narrowing of blood vessels). Trental belongs to a group of drugs called methylxanthine derivatives, which improve blood flow by decreasing the thickness of blood.
This medication comes in tablet form and is usually taken 3 times a day, with meals.
Common side effects of Trental include upset stomach, vomiting, gas, and headache. Trental can also cause dizziness. Do not drive or operate heavy machinery until you know how Trental affects you.
Before taking Trental, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
- are allergic to Trental or to any of its ingredients or to other methylxanthine derivatives, including caffeine, theophylline, and theobromine
- have had a recent cerebral and/or retinal hemorrhage
- have or have had kidney disease
- are having surgery, including dental surgery
- are pregnant or plan to become pregnant
- are breastfeeding or plan to breastfeed
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
If you take too much Trental, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What other drugs will affect Trental (pentoxifylline)?
If you also take a blood thinner such as warfarin (Coumadin, Jantoven), you may need more frequent "INR" or prothrombin time tests to measure your blood-clotting time.
Other drugs may interact with pentoxifylline, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Uses For Trental
Pentoxifylline improves the flow of blood through blood vessels. It is used to reduce leg pain caused by poor blood circulation. Pentoxifylline makes it possible to walk farther before having to rest because of leg cramps.
Pentoxifylline is available only with your doctor's prescription.
Trental should not be used in patients with recent cerebral and/or retinal hemorrhage or in patients who have previously exhibited intolerance to this product or methylxanthines such as caffeine, theophylline, and theobromine.
Trental Dosage and Administration
The usual dosage of Trental in extended-release tablet form is one tablet (400 mg) three times a day with meals.
While the effect of Trental may be seen within 2 to 4 weeks, it is recommended that treatment be continued for at least 8 weeks. Efficacy has been demonstrated in double-blind clinical studies of 6 months duration.
Digestive and central nervous system side effects are dose related. If patients develop these effects it is recommended that the dosage be lowered to one tablet twice a day (800 mg/day). If side effects persist at this lower dosage, the administration of Trental should be discontinued.
PRINCIPAL DISPLAY PANEL - Label
pentoxifylline tablet, film coated, extended release
|Labeler - Sanofi-Aventis U.S. LLC (824676584)|
|Valeant Pharmaceuticals International Inc.||248902996||MANUFACTURE(0039-0078), ANALYSIS(0039-0078), LABEL(0039-0078), PACK(0039-0078)|