Name: Zyrtec-D

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

For Healthcare Professionals

Applies to cetirizine / pseudoephedrine: oral tablet extended release


Dermatologic side effects have included maculopapular and urticarial eruptions.[Ref]


Gastrointestinal side effects of cetirizine have included dry mouth (5.7%) and nausea or vomiting (2.2%). Pharyngitis, dyspepsia, and increased appetite have occasionally been reported.

Gastrointestinal adverse effects of pseudoephedrine have included anorexia and gastric irritation (5%). Dry mouth, nose, or throat have occurred in up to 15% of patients.[Ref]


Hepatic side effects have included rare liver function test abnormalities which resolved spontaneously following discontinuation of cetirizine therapy.[Ref]

Nervous system

Cetirizine appears to be more sedating than terfenadine, astemizole, and loratadine.[Ref]

Nervous system side effects of cetirizine administration have included headache (16%), fatigue (5.6%), and somnolence (5% to 20%). Somnolence tends to be dose-related and generally occurs more frequently with doses higher than 10 mg per day. Other nervous system side effects include dizziness (1.8%), insomnia (1.5%), and nervousness (1.1%). Post marketing reports have included aggression reaction and convulsions.

Nervous system side effects of pseudoephedrine have included insomnia in up to 30% of patients. Tremor, anxiety, nervousness, and headache have also been reported.[Ref]


Respiratory side effects have included wheezing, coughing, bronchitis, sinusitis, and asthma.[Ref]


Hypersensitivity reactions have included fixed drug eruptions with pseudoephedrine use.[Ref]


Cardiovascular side effects have included tachycardia. Some patients have developed hypertension and/or arrhythmias.[Ref]


General side effects have included epistaxis (1.1%) and accidental injury (1.1%).[Ref]

Some side effects of Zyrtec-D may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.